Sub-regional Hippocampus Glutamate Changes in a Mouse Model of Tau Pathology Measured by GluCEST
نویسندگان
چکیده
Sub-regional Hippocampus Glutamate Changes in a Mouse Model of Tau Pathology Measured by GluCEST Rachelle Crescenzi, Catherine DeBrosse, Ravi Prakash Reddy Nanga, Hari Hariharan, Ari Borthakur, John Detre, Virginia M.-Y. Lee, and Ravinder Reddy Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, United States, Center for Magnetic Resonance and Optical Imaging (CMROI), University of Pennsylvania, Philadelphia, PA, United States, Center for Functional Neuroimaging (CfN), University of Pennsylvania, Philadelphia, PA, United States, Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania, Philadelphia, PA, United States
منابع مشابه
High Resolution Mapping of Modafinil Induced Changes in Glutamate Level in Rat Brain
Modafinil is marketed in the United States for the treatment of narcolepsy and daytime somnolence due to shift-work or sleep apnea. Investigations of this drug in the treatment of cocaine and nicotine dependence in addition to disorders of executive function are also underway. Modafinil has been known to increase glutamate levels in rat brain models. Proton magnetic resonance spectroscopy (1HMR...
متن کاملCholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
متن کاملCholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
متن کاملRiluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.
Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(TauP301L)4510 mouse model of AD. To determine whether improving glutamate regu...
متن کاملMapping glutamate in subcortical brain structures using high-resolution GluCEST MRI.
In vivo measurement of glutamate (Glu) in brain subcortex can elucidate the role these structures play in cognition and neuropsychiatric disorders. However, accurate quantification of Glu in subcortical regions is challenging. Recently, a novel MRI method based on the Glu chemical exchange saturation transfer (GluCEST) effect has been developed for detecting brain Glu in millimolar concentratio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013